No, really?

(Mother Jones) The team found that when fruit flies are fed regular doses of sucralose (brand name: Splenda) over an extended period, they consume 30 percent more calories (compared to sucralose-free control flies) when they they have access to naturally sweetened food. And when the team removed the sucralose, the effect vanished.

Because in the end Mother Nature is still supreme, no matter how much we try to chemically improve on her.